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INFORMATION DISC 
CITATION 



PTO-1449 



EXAMINER'S 
INITIALS 



PATENT NO. 




SHEET 1 OF 1 



ATTY. DOCKET NO. 
A-64558-1/R FT/RMS 



SERIAL NO. 
08/873,597 



APPLICANT 
KAYYEMetal. 



FILING DATE 
June 12. 1997 



GROUP 
1634 



DATE 



PATENT DOCUMENTS 



NAME 



CLASS 



SUBCLASS 



FILING DATE 



i-^MmM:ri ms mm. 



EXAMINER'S 
INITIALS 



PATENT NO. 



DATE 



JORiGNi^ 



COUNTRY 



CLASS 



SUBCLASS 



Translation 



RR 



6-41183 



2/15/1994 



Japan 



WW 



, Etc 



EX/\MINER 



DAXE CONSIDERED 



SfsS' liSi o?S^S^ '^^'^ ?'"^" " ««h MPEP 609; draw line through citation if not in conformance and not 

consiaerea. include copy of this form with next communication to applicant. — 



8085 1449AFRM (8/95) 



SHEET 1 OF 11 




INFORMATION DISCLOSURE 
CITATION 

PTO-1449 



ATTY. DOCKET NO. 
A-64558-l/RFT/RMS 



SERIAL NO. 
08/873,597 



APPLICANT 
Kayyem, et aL 



FILING DATE 
June 12, 1997 



GROUP 

Not Assigned 



U.S. PATENT DOCUMENTS 



EXAwrmtTTS 
INITIALS 



PATENT NO. 



DATE 



NAME 



CLASS 



SUBCLASS 



FlUNG DATE 



5^ 



4,707,352 



11/17/87 



Stavrianopoulos 



4,707,440 



11/1987 



Stavrianopoulos 



435 



4,711,955 



1 2/8/87 



Ward, et al. 



4,755,458 



7/5/88 



Rabbani, et al. 



4,849,513 



7/1 8/89 



Smith, et al. 



536 



27 



4,868,103 



9/1 9/89 



Stavrianopoulos, et al. 



4,894,325 



1/16/90 



Englehardt, et al. 



H 



4,943,523 



7/24/90 



Stavrianopoulos 



4,952,685 



8/28/90 



Stavrianopoulos 



4,994,373 



2/19/91 



Stavrianopoulos 



5,002,885 



3/26/91 



Stavrianopoulos 



5,013,831 



5/7/91 



Stavrianopoulos 



FOREIGN PATENT DOCUMENTS 



EXAMINER'S 
INITIALS 



PATENT NO. 



DATE 



COUNTRY 



CLASS 



SUBCLASS 



Translation 



Yes 



No 



M 



0 63879 



11/3/82 



Europe 



N 



9 210 757 



6/25/92 



PCT (WO) 



9 515 971 



6/1 5/95 



PCT (WO) 



Ha 



0 234938 



2/26/87 



EP (A2) 



OTHER DOCUMEriTS (Including Author, Title, Date, Pertinent Pages, Etc.) 




Alleman, K.S., et al., "Electrochemical Rectification at a Monolayer-Modified Electrode," J. Phys. 
Chem., 100:17050-17058 (1996). 



Arkin et al. "Evidence for Photoelectron Transfer Through DNA Intercalation," J. Inorganic Biochem. 
Ahstrants. 6th IntRrnatinnal Conference on Bioinoraanin Chemistry. 51(1) & (2>:526 n993>. 



EXAMINER 




EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609; draw line through citation if not in conformance and 
not considered. Include copy of this form with next communication to applicant. 

563615 




INFORMATION DISCLOSURE 
CITATION 

PTO-1449 



ATTY. DOCKET NO. 
A-64558-1/RFT/RMS 



SERIAL NO. 
08/873,597 



APPLICANT 
Kayyem, et al. 



FILING DATE 
June 12, 1997 



GROUP 

Not Assigned 



EXAMINER'S 
INITIALS 



U.S. PATENT DOCUMENTS 



PATENT NO. 



DATE 



NAME 



CLASS 



SUBCLASS 



FILING DATE 



5,082,830 



1/21/92 



Brakel, et al 



5,175,269 



12/29/92 



Stavrianopoulos 



5,241,060 



8/31/93 



Englehardt, et al. 



4 



5,278,043 



i/ii/9y^ 



Bannwarth, et al. 



536 



23.1 



U 



5,312,527 



5/17/94 



Mikkelsen, et al. 



204 



153.12 



V 



5,328,824 



7/1 2/94 



Ward, et al. 



W 



5,449,767 



9/12/95 



Ward, et al.- 



5,472,881 



12/95 



Beebe, et al. 



436 



94 



5,/76,928 



5,/ 

6? 



12/19/95 



Ward, et al. 



3 



5^95,908 



1/21/97 



Fawcett, et al. 



534 



11 



AA 



5,565,552 



10/15/96 



Magda, et al. 



534 



11 



BB 



5,573,906 



11/12/96 



Bannwarth, et al. 



435 



CC 



5,591,578 



1/7/97 



Meade, et al. 



435 



DD 



5,601,982 



2/1997 



Sargent, et al. 



435 



FOREIGN PATENT DOCUMENTS 



EXAMINER'S 
INITIALS 



PATENT NO. 



DATE 



COUNTRY 



CLASS 



SUBCLASS 



Translation 



Yes 



No 



EE 



9 310 267 



5/27/93 



PCT (WO) 



FF 



2 090904 



9/24/93 



CANADA 



GG 



0 599337 



1/16/94 



EPO 



HH 



238,166.0 



988 



JP (Abstract (63-238166)) 



0 229943 



7/29/87 



EP 



JJ 



9 640712 



12/19/96 



WO 



OTHER DOCUMENTS (Including Author, Title, Date, Pertinent Pages, Etc.) 




DATE CONSIDERED 



EXAMINER: Initial if reference considered, whether or not citation is in confornnance with MPEP 609; draw line through citation if not in conformance and 



SHEET 3 OF 11 



INFORMATION DISCLOSURE 
CITATION 

PTO-1449 




ATTY. DOCKET NO. 
A-64558-l/RFT/RMS 



SERIAL NO. 
08/873,597 



APPLICANT 
Kayyem, et al. 



FILING DATE 
June 1, 1997 



GROUP 

Not Assigned 



OTHER DOCUMENTS (Including Author, Title, Date, Pertinent Pages, Etc.) 



Barisci, et al., "Conducting Polymer Sensors," TRIP, 4(9):307-311 (1996). 



Baum, R. M., "Views on Biological, Long-Range Electron Transfer Stir Debate," C&EN, pp 20-23 
(1993). 



Bechtold, R., et al., "Ruthenium-Modified Horse Heart Cytochrome c: Effect of pH and Ligation on 
the Rate of Intramolecular Electron Transfer between Ruthenium(ll) and Heme(lll)/' J, Phys, Chem., 
90(16):3800-3804 (1986). 



BIdan, "Eiectroconducting conjugated polymers: new sensitive matrices to build up chemical or 
electrochemical sensors. A Review.," Sensors and Actuators, B6:45-56 (1992). 



Biotechnology and Genetics: Genetic Screening Integrated Circuit," The Economist (February 25- 
March 3, 1995). 



Boguslavsky, L. et al., "Applications of redox polymers in biosensors/' Solid State Ionics, 60:189- 
197 (1993). 



Bowler, B. E., et al., "Long-Range Electron Transfer in Donor (Spacer) Acceptor Molecules and 
Proteins," Progress in inorganic Chemistry: Bioinorganic Chemistry, 38:259-322 (1990). 



10 



Brun, A. M., et al., "Photochemistry of Intercalated Quaternary Diazaaromatic Salts," J. Am. Chem. 
Soc, 113:8153-8159 (1991). 



11 



Bumm, et al., "Are Single Molecular Wires Conducting?," Science 271:1705-1707 (1996). 



12 



Cantor, C.R. et al., "Report on the Sequencing by Hybridization Workshop," Genomics, 13:1378- 
1383(1992). 



13 



Chang, l-Jy, et al., "High-Driving-Force Electron Transfer in Metalloproteins: Intramolecular 
Oxidation of Ferrocytochrome c by Ru(2,2'-bpy)2(im)(His-33)^+," J. Am. Chem. Soc, 113:7056- 
7057 (1991). 



14 



Chidsey, CE.D., et a!., "Free Energy and Temperature Dependence of Electron Transfer at the 
Metal Electrolyte Interface," Science, 251:919-923 (1991). 




Chidsey, et al., "Coadsorption of Ferrocene-Terminated and Unsubstituted Alkanethiols on Gold*' 
Electroactive Self -Assembled Monolayers," J, Am. Chem. Soc, 1 1 2:4301-4306 (1990). 



EXAMINER 



CONSIDERED 



EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609; draw line through citation if not in conformance and 
not considered. Include copy of this form with next communication to applicant. 

563615 



SHEET 4 OF 11 




PRMATION DISCLOSURE 
CITATION 

PTO-1449 



ATTY. DOCKET NO. 
A'64558-1/RFT/RMS 



SERIAL NO. 
08/873,597 



APPLICANT 
Kayyem, et aL 



FILING DATE 
June 12, 1997 



GROUP 

Not Assigned 



OTHER DOCUMENTS (Including Author, Title, Date, Pertinent Pages, Etc.) 



5(1 



16 



Chrisey, et al., "Covalent attachment of synthetic DNA to self-assembled monolayer films/' Nucleic 
Acids Research, 24(1 5):3031 -3039 (1996). 



17 



Clery, "DNA Goes Electric/' Science, 267:1270 (1995). 



18 



Commerce Business Daily Issue of September 26, 1 996 PSA#1 688. 



19 



DATABASE WPI, Derwent Publications Ltd., London, GB; AN 88-320199 & JP, A, 53 238 166 
(MITSUBISHI DENKI KK), 4 October 1988. 



20 



Davis, L. M., et a!., "Electron Donor Properties of the Antitumour Drug Amsacrine as Studied by 
Fluorescence Quenching of DNA-Bound Ethidium/' Chem.-Biol. Interactions, 62:45-58 (1987). 



21 



Davis, L. M., et al., "Elements of biosensor construction," Enzyme Microb. Technol. 17:1030-1035 
(1995). 



22 



Degani et al., "Direct Electrical Communication between Chemically Modified Enzymes and Metal 
Electrodes. 2. Methods for Bonding Electron-Transfer Relays to Glucose Oxidase and D-Amino-Acid 
Oxidase," J. Am. Chem. Soc, 1 10:261 5-2620 (1988). 



23 



Degani, Y., et al., "Electrical Communication between Redox Centers of Glucose Oxidase and 
Electrodes via Electrostatically and Covalently Bound Redox Polymers," J. Am. Chem, Soc, 
111:2357-2358 (1989). 



24 



Degani, Y., et al., "Direct Electrical Communication between Chemically Modified Enzymes and 
Metal Electrodes. 1. Electron Transfer from Glucose Oxidase to Metal Electrodes via Electron 
Relays, Bound Covalently to the Enzyme," J. Phys, Chem., 91 (6):1 285-1 288 (1987). 



25 



Deinhammer, R.S., et a!., "Electronchemical Oxidation of Amine-containing compounds: A Route to 
the Surface Modification of glassy carbon electrodes," Langmuir, 10:1306-1313 (1994). 




26 



Dreyer, G. B., et al., "Sequence-specific cleavage of single-stranded DNA: Oligodeoxynucleotide- 
EDTA-Fe(ll)," Proc. NatL Acad. ScL USA, 82:968-972 (1985). 



27 



Durham, B., et al., "Photoinduced Electron-Transfer Kinetics of Singly Labeled Ruthenium 
Bis(bipyridin) Dicarboxybipyridine Cytochrome c Derivatives," Biochemistry, 28:8659-8665 (1989). 



28 



Durham, B., et al., "Electron-Transfer Kinetics of Singly Labeled Ruthenium(ll) Polypyridine 
Cytochrome c Derivatives," >!|/ne/'/ca/7 Chemical Society, pages 181-193 (1990). 



1 lf}/j .r^..^^ .aIdATECOI 



EXAMINER 



DATE CONSIDERED 



EXAMINER: Initial if reiQrence considered, whether or not citation is in conformance with MPEP 609; draw line through citation if not in conformance and 
not considered. Include copy of this form with next communication to applicant. 56361 5 



SHEET 5 OF 11 



INFORMATION DISCLOSURE 
CITATION 




PTO-1449 



ATTY. DOCKET NO. 
A-64558-1/RFT/RMS 



SERIAL NO. 
08/873,597 



APPLICANT 
Kayyem, et al. 



FILING DATE 
June 12, 1997 



GROUP 

Not Assigned 



OTHER DOCUMENTS (including Author, Title, Date, Pertinent Pages, Etc.) 



29 



Elias, H., et al., "Electron-Transfer Kinetics of Zn-Substituted Cytochrome c and Its 
Ru(NH3)5{Histidine-33) Derivative/' J. Chem, Soc, 110:429-434 (1988). 



30 



Farver, O., et al., "Long-range intramolecular electron transfer in azurins," Proc. Natl. Acad. ScL 
USA, 86:6968-6972 (1989). 



31 



Fox, L. S., et al., "Gaussian Free-Energy Dependence of Electron-Transfer Rates in Iridium 
Complexes," Sc/ence, 247:1069-1071 (1990). 



32 



Fox, M. A., et al., "Light-Harvesting Polymer Systems/' C&EN, pages 38-48 (March 15, 1993). 



33 



Francois, J-C, et al., "Periodic Cleavage of Poly(dA) by Oligothymidylates Covalently Linked to the 
1,10-Phenanthroline-Copper Complex," Biochemistry, 27:2272-2276 (1988). 



34 



Friedman, A. E., et al., "Molecular 'Light Switch' for DNA: Ru(bpy)2(dppz)2^," J. Am. Chem. Soc, 
112:4960-4962 (1990). 



35 



Fromherz, P., et al., "Photoinduced Electron Transfer in DNA Matrix from Intercalated Ethidium to 
Condensed Methylviologen," J, Am, Cliem. Soc, 108:5361-5362 (1986). 



36 



Gardner, et^l,, "Application of conducting polymer technology in microsystems," Sensors and 
Actuators, A5 1:57-66 (1995). 



37 



Gregg, B. A., et al., "Cross-linked redox gels containing glucose oxidase for amperometric biosensor 
applications," >4/7a/. Chem., 62:258-263 (1990). 



38 



Gregg, B. A,, et al., "Redox Polymer Films Containing Enzymes. 1. A Redox-Conducting Epoxy 
Cement: Synthesis, Characterization, and Electrocatalytic Oxidation of Hydroqulnone," J. Phys. 
Chem., 96:5970-5975 (1991). 



39 



Hashimoto, et al., "Sequence-Specific Gene Detection with a Gold Electrode Modified with DNA 
Probes and an Electrochemically Active Dye," Ana/. Chem. 66:3830-3833 (1994). 




40 



Hegner, et al., "Immobilizing DNA on gold via thiol modification for atomic force microscopy 
imaging in buffer solutions," FEBS 336(3) :452-456 (1993). 



41 



Heller, A., et al., "Amperometric biosensors based on three-dimensional hydrogel-forming epoxy 
netyAforks," Sensors and Actuators, 13-14:180-183 (1993). 




EXAMINER 



CONSIDERED 



EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609; draw line through citation if not in conformance and 
not considered. Include copy of this form with next communication to applicant. 

563615 




INFORMATION DISCLOSURE 
CITATION 

/O ^ ^^Ny PTO-1449 

/ ^ 
J M26m 


ATTY. DOCKET NO. 
A-64558-1/RFT/RMS 


SERIAL NO. 
08/873,597 


APPLICANT 
Kayyem, et al. 


FILING DATE 
June 12, 1997 


GROUP 

Not Assigned 




Cfl 

My ointri LrLroufvicAi i o iinciuainQ MuxnOTf iiiie, uaXB, renmeni rages, cIC.i 


1 






teller, A., "Electrical Wiring of Redox Enzymes/' Acc. Chem. Res., 23:128-134 (1990). 








43 


Heller et al., "Fluorescent Energy Transfer Oligonucleotide Probes/' Fed. Proc. 46(6): 1968 (1987) 
Abstract No. 248. 








44 


Ho "DNA-Mediated Electron Transfer and Application to 'Biochip'Development, " >^/)sfracf. Office of 
Naval Research (Report Date: July 25, 1991) 1-4, RR04106. 








45 


Hobbs et al., "Polynucleotides Containing 2'-Amino-2'deoxyribose and 2'-A2ido-2'-deoxyriose/' 
Biochemistry, /2r25):5138-5145 (1973). 








46 


Hsung, et al., "Synthesis and Characterization of Unsymmetric Ferrocene-Terminated Phenylethynyl 
Oligomers/' Organometallics, 14:4808-4815 (1995). 








47 


Hsung, et al., 'Thiophenol Protecting Groups for the Palladium-Catalyzed Heck Reaction: Efficient 
Syntheses of Conjugated Arylthiols/' Tetrahedron Letters. 36(26):4525-4528 (1995). 








48 


Jenkins et al., "A Sequence-Specific Molecular Light Switch: Tebhering of an Oligonucleotide to a 
Dipyridophenazine Complex of Ruthenium (II), J. Am. Chem. Soc, 114:8736-8738 (1992). 








49 


Katritzky, et al., "Pyridylethylation - A New Protection Method for Active Hydrogen Compounds," 
Tetrahedron Z.effers,25( 12): 1223-1 226 (1984). 








50 


Kelley, S.O. and J.K. Barton, "Electrochemistry of Methylene Blue Bound to a DNA-Modified 
Electrode," B/oconjugate Chem., 8:31-37 (1997). 








51 


Kojima et al., "A DNA Probe of Ruthenium Bipyridine Complex Using Photocatalytic Activity," 
Chemistry Letter, pp 1889-1982 (1989). 








52 


Laviron, E., "A.C, Polarography and Faradaic Impedance of Strongly Adsorbed Electroactive 
Species. Part 1: Theoretical and Experimental Study of a Quasi-Reversible Reaction in the Case of a 
Langmuir Isotherm," J. ElectroanaL Chem., 97:135-149 (1979). 








53 


Laviron, E., "A.C. Polarography and Faradaic Impedance of Strongly Adsorbed Electoactive 
Species. Part III: Theoretical Complex Plane Analysis for a Surface Redox Reaction," J. ElectroanaL 
Chem., 105:35-42 (1979). 




V 






EXAMINER A VY] ^ , bATE CONSIDERED ^//fr/ 



EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609; draw line through citation if not in conformance and 
not considered. Include copy of this form with next communication to applicant. 



SHEET 7 OF 11 



INFORMATION DISCLOSURE 
CITATION 




PTO-1449 



ATTY. DOCKET NO. 
A-64558-1/RFT/RMS 



SERIAL NO. 
08/873,597 



APPLICANT 
Kayyem, et al. 



FILING DATE 
June 12, 1997 



GROUP 

Not Assigned 



OTHER DOCUMENTS {Including Author, Title, Date, Pertinent Pages, Etc.) 



Lee, et al., "Direct Measurement of the Forces Between Complementary Strands of DNA," Science, 
IQQ'Jl^-llZ (1994). 



55 



Lenhard, J.R., et a!., "Part VII Covalent Bonding of a Reversible- Electrode Reactanbt to Pt 
Electrodes Using an organosiiane Reagent" J. Electronal. Chem., 78:195-201 (1977), 



56 



Lipkin "Identifying DNA by the Speed of Electrons," Science News, 147(8):1 17 ( 1995). 



57 



Maskos, et al., "Oligonucleotide hybridisations on glass supports: a novel linker for oligonucleotide 
synthesis and hybridisation properties of oligonucleotides synthesised in situ/' Nucieic Acids 
Research, 20(7):1 679-1 684 (1992). 



58 



Mazzocchi, Ph.H. and G. Fritz, "Photolysis of N-(2-Methyl-2-Propenyl)phthalimide in Methanol. 
Evidence Supporting Radical-Radical Coupling of a Photochemically Generated Radical Ion Pair,' 
Journal of the American Chemical Society, 108(1 8):5361-5362 (1986). 



59 



McGee, et al., "2*-Amino-2'-deoxyuridine via an Intramolecular Cyclization of a 
Trichloroacetimidate," J. Org, Chem,, 61:781-785 (1996). 



60 



Meade, T. J., "Driving-Force Effects on the Rate of Long-Range Electron Transfer in Ruthenium- 
Modified Cytochrome c," J, Am, Chem, Soc, 111:4353-4356 (1989). 



61 



Meade, T. J., et al., "Electron Transfer through DNA: Site-Specific Modification of Duplex DNA 
with Ruthenium Donors and AccB\iXoTs, " Angew Chem, Int. Ed. Engl., 34:352 (1995). 



62 



Mestel, "'Electron Highway' Points to Identity of DNA," New Scientist, p. 21 (1995). 



63 



Millan, et al., "Voltammetric DNA Biosensor for Cystic Fibrosis Based on a Modified Carbon Paste 
Electrode," .4/7aA Chem., 66:2943-2948 (1994). 



64 



Millan, K.M., et al., "Covalent Immobilization of DNA onto Glassy Carbon Electrodes," 
Electroanalysis, 4:929-932 (1992). 




65 



Millan, K.M. and Mikkelsen, S.R., "Sequence-Selective Biosensor for DNA Based on Electroactive 
Hybridization Indicators," >l/7a/. Chem., 65:2317-2323 (1993). 



EXAMINER 



^TE CONSIDERED a 



EXAMINER: Initial if reference considered, whether or not citation is in conformance with MPEP 609; draw line through citation if not in conformance and 
not considered. Include copy of this form with next communication to applicant. 56361 5 



SHEET 8 OF 11 




INFORMATION DISCLOSURE 
CITATION 



PTO-1449 

JAN 2 6 figg ^] 



ATTY. DOCKET NO. 
A-64558-1/RFT/RMS 



SERIAL NO. 
08/873,597 



APPLICANT 
Kayyem, et al. 



FILING DATE 
June 1 2, 1 997 



GROUP 

Not Assigned 



OTHER DOCUMENTS (Including Author, Title, Date, Pertinent Pages, Etc.) 



Miller, C, "Absorbed a)-Hydroxy Thiol Monolayers on Gold Electrodes: Evidence for Electron 
Tunneling to Redox Species in Solution," J. Phys. Chem,, 95:877-886 (1991). 



Murphy, C. J., et al., "Long-Range Photoinduced Electron Transfer Through a DNA Helix," Science, 
262:1025-1029 (1993). 



68 



Orellana, G., et al., "Photoinduced Electron Transfer Quenching of Excited Ru(ll) Polypyridyls Bound 
to DNA: The Role of the Nucleic Acid Double Helix," Photochemistry and Photobiology, 54(4):499- 
509 (1991). 



69 



Palecek, "From Polarography of DNA to Microanalysis with Nucleic Acid-Modified Electrodes,' 
Electroanalysis. 8(1): 7- 14 (1996). 



/ 



70 



Peterson, "Electric Genes: Current Flow in DNA Could Lead to Faster Genetic Testing," Scientific 
American, 33-34 (May 1995). 



71 



Purugganan, M. D., et al., "Accelerated Electron Transfer Between Metal Complexes Mediated by 
DNA, Science, 241:1645-1649 (1988). 



72 



Rhodes, D. And A. Klug, "Helical Periodicity of DNA Determined by Enzyme Digestion," Nature, 
286:573-578 (1980). 



73 



Risser, S. M., et al., "Electron Transfer in DNA: Predictions of Exponential Growth and Decay of 
Coupling with Donor-Acceptor Distance," J. Am. Chem. Soc, 1 15(6):2508-2510 (1993). 



74 



Sato, Y., et al., "Unidirectional Electron Transfer at Self-Assembled Monolayers of 1 1-Ferrocenyl-1- 
undecanethiol on Gold," Buil. Chem. Soc. Jpn,, 66(4):1 032-1 037 (1993). 



75 



Satyanarayana, S., et aL, "Neither A- nor A-Tris(phenanthroline)ruthenium(ll) Binds to DNA by 
Classical Intercalation," Biochemistry, 31 (39):931 9-9324 (1992). 




76 



Schreiber, et al., "Bis(purine) Complexes of ?ra/7s-a2Pt": Preparation and X-ray Structures of Bis(9- 
methyladenine) and Mixed 9-Methyladenine, 9-Methylguanine Complexes and Chemistry Relevant to 
Metal-Modified Nucelobase Triples and Quartets," J. Am. Chem, Soc, 118:4124-4132 (1996). 



EXAMINER ^ ^y^- 



^4 



I ATE CiDNSIDERED 



EXAMINER: Initial if reference considered, whether or not citation is in confornnance with MPEP 609; draw line through citation if not in conformance and 
not considered. Include copy of this form with next communication to appl(cant.5636i5 




INFORMATION DISCLOSURE 
^ ^ CITATION 

/ «A PTO-1449 
1 JAN ?61S98 ^ 


ATTY. DOCKET NO. 
A-64558-1/RFT/RMS 


SERIAL NO. 
08/873,597 


APPLICANT 
Kayyem, et al. 


FILING DATE 
June 12, 1997 


GROUP 

Not Assigned 


^^^7i>Anoi^^ OTHER DOCUMENTS (Including Author, Title, Date, Pertinent Pages, Etc.) 






I 




Schuhmann, W., et al., "Electron Transfer between Glucose Oxidase and Electrodes via Redox 
Mediators Bound with Flexible Chains to the Enzyme Surface," J. Am. Chem, Soc, 1 13:1394-1397 
(1991). 








78 


Schumm, et al., "Iterative Divergent/Convergent Approach to Linear Conjugated Oligomers by 
Successive Doubling of the Molecular Length: A Rapid Route to a 128 A-Long Potential Molecular 
W\XQr Angew. Chem. Int Ed. EngL, 33(1 1):1360-1 363 (1994). 






79 


Sigal et al., "A Self-Assembled Monolayer for the Binding and Study of HIstidine-Tagged Proteins by 
Surface Plasmon Resonance," Anal. Chem., 68(3):490-497 (1996). 






80 


Southern, et al., "Arrays of complementary oligonucleotides for analysing the hybridisation 
behaviour of nucleic acids," Nucleic Acids Research, 22(8) :1 368-1 373 (1994). 






81 


Strobel, S. A., et al., "Site-Specific Cleavage of a Yeast Chromosome by Oligonucleotide-Directed 
Triple-Helix Formation," Science, 249:73-75 (1990). 






82 


Su, et al., "Interfacial Nucleic Acid Hybridization Studied by Random Primer ^^P Labelling and Liquid- 
Phase Acoustic Network Ana\ys\s/' Analytical Chemistry, 66(6):769-777 (1994). 






83 


Telser, J., et ah, "DNA Duplexes Covalently Labeled at Two Sites: Synthesis and Characterization 
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